Extracellular Signal-Regulated Kinase 2 Signaling in the Hippocampal Dentate Gyrus Mediates the Antidepressant Effects of Testosterone

@article{Carrier2012ExtracellularSK,
  title={Extracellular Signal-Regulated Kinase 2 Signaling in the Hippocampal Dentate Gyrus Mediates the Antidepressant Effects of Testosterone},
  author={Nicole Hollabaugh Carrier and Mohamed Kamal Kabbaj},
  journal={Biological Psychiatry},
  year={2012},
  volume={71},
  pages={642-651}
}
BACKGROUND Human and animal studies suggest that testosterone may have antidepressant effects. In this study, we sought to investigate the molecular mechanisms underlying the antidepressant effects of testosterone within the hippocampus, an area that is fundamental in the etiology of depression. METHODS The effects of testosterone replacements in gonadectomized adult male rats were investigated using the sucrose preference and forced swim tests. We explored possible effects of testosterone on… CONTINUE READING
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