Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages

@article{Fogarty2016ExtracellularRO,
  title={Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages},
  author={Caitlin E. Fogarty and Neha Diwanji and Jillian L. Lindblad and Meghana Tare and Alla Amcheslavsky and Kalpana Makhijani and Katja Br{\"u}ckner and Yun Fan and Andreas Bergmann},
  journal={Current Biology},
  year={2016},
  volume={26},
  pages={575-584}
}
Apoptosis-induced proliferation (AiP) is a compensatory mechanism to maintain tissue size and morphology following unexpected cell loss during normal development, and may also be a contributing factor to cancer and drug resistance. In apoptotic cells, caspase-initiated signaling cascades lead to the downstream production of mitogenic factors and the proliferation of neighboring surviving cells. In epithelial cells of Drosophila imaginal discs, the Caspase-9 ortholog Dronc drives AiP via… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 55 references

Evolution of TNFsignalingmechanisms:JNK-dependent apoptosis triggeredbyEiger, theDrosophilahomolog of the TNF superfamily

E. Moreno, M. Yan, K. andBasler
Curr. Biol • 2002
View 4 Excerpts
Highly Influenced

Paracrine signaling mediated at cell-cell contacts.

BioEssays : news and reviews in molecular, cellular and developmental biology • 2015

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