Extracellular NM23 protein promotes the growth and survival of primary cultured human acute myelogenous leukemia cells.

@article{OkabeKado2009ExtracellularNP,
  title={Extracellular NM23 protein promotes the growth and survival of primary cultured human acute myelogenous leukemia cells.},
  author={Junko Okabe‐Kado and Takashi Kasukabe and Yoshio Honma and Hirofumi Kobayashi and Nobuo Maseki and Yasuhiko Kaneko},
  journal={Cancer science},
  year={2009},
  volume={100 10},
  pages={
          1885-94
        }
}
An elevated serum level of NM23-H1 protein is found in acute myelogenous leukemia (AML), and predicts a poor treatment outcome in AML patients. To investigate the potential pathological link between the elevated serum level of this protein and poor prognosis, we examined the extracellular effects of recombinant NM23-H1 protein on the in vitro growth and survival of primary cultured AML cells at concentrations equivalent to the levels found in the serum of AML patients. Extracellular NM23-H1… CONTINUE READING

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