Extracellular NAADP affords cardioprotection against ischemia and reperfusion injury and involves the P2Y11-like receptor.

@article{Djerada2013ExtracellularNA,
  title={Extracellular NAADP affords cardioprotection against ischemia and reperfusion injury and involves the P2Y11-like receptor.},
  author={Zoubir Djerada and H{\'e}l{\`e}ne Peyret and Sylvain F. Dukic and Herv{\'e} Millart},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={434 3},
  pages={428-33}
}
BACKGROUND AND PURPOSE Extracellular nucleotides may play important regulatory roles within the cardiovascular system and notably in cardioprotection. We aimed to look for a possible pharmacological preconditioning effect of extracellular NAADP ([NAADP]e) against ischemia/reperfusion injury. [NAADP]e has been recently reported to be a full agonist of the P2Y11 receptor. Therefore, we characterized the involvement of the P2Y11-like receptor in mediating ischemic/reperfusion tolerance induced by… CONTINUE READING