Extracellular N-acetylaspartate in the rat brain: in vivo determination of basal levels and changes evoked by high K+.

@article{Taylor1994ExtracellularNI,
  title={Extracellular N-acetylaspartate in the rat brain: in vivo determination of basal levels and changes evoked by high K+.},
  author={Deanna L. Taylor and Si{\^a}n E. C. Davies and Tihomir P. Obrenovitch and Jutta Urenjak and D. A. Richards and John Bates Clark and L. Sokoloff M. Spatz W. E. Stehbens L. Symon},
  journal={Journal of neurochemistry},
  year={1994},
  volume={62 6},
  pages={2349-55}
}
The purpose of this study was to determine the extracellular concentrations of N-acetylaspartate (NAA) in the rat cerebral cortex, striatum, and hippocampus of halothane-anaesthetised rats by intracerebral microdialysis, and to examine the effects of high K(+)-induced local depolarisation, which provokes synchronous neurotransmitter release, cell swelling, and acid-base changes. Basal levels of NAA in the extracellular fluid (ECF) were determined by the zero net flux method. Tissue levels of… CONTINUE READING

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