Extracellular Matrix-Mediated Maturation of Human Pluripotent Stem Cell-Derived Cardiac Monolayer Structure and Electrophysiological Function.

@article{Herron2016ExtracellularMM,
  title={Extracellular Matrix-Mediated Maturation of Human Pluripotent Stem Cell-Derived Cardiac Monolayer Structure and Electrophysiological Function.},
  author={Todd J. Herron and Andr{\'e} Monteiro da Rocha and Katherine F. Campbell and Daniela Ponce-Balbuena and B Cicero Willis and Guadalupe Guerrero-Serna and Qinghua Liu and Matt Klos and Hassan A-A Musa and Manuel Zarzoso and Alexandra Bizy and Jamie Furness and Justus M. B. Anumonwo and Sergey Mironov and Jos{\'e} Jalife},
  journal={Circulation. Arrhythmia and electrophysiology},
  year={2016},
  volume={9 4},
  pages={e003638}
}
BACKGROUND Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) monolayers generated to date display an immature embryonic-like functional and structural phenotype that limits their utility for research and cardiac regeneration. In particular, the electrophysiological function of hPSC-CM monolayers and bioengineered constructs used to date are characterized by slow electric impulse propagation velocity and immature action potential profiles. METHODS AND RESULTS Here, we have… CONTINUE READING
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