Extracellular Matrix-Mediated Control of Aortic Smooth Muscle Cell Growth and Migration by a Combination of Ascorbic Acid, Lysine, Proline, and Catechins

@article{Ivanov2007ExtracellularMC,
  title={Extracellular Matrix-Mediated Control of Aortic Smooth Muscle Cell Growth and Migration by a Combination of Ascorbic Acid, Lysine, Proline, and Catechins},
  author={Vadim Ivanov and Svetlana Ivanova and Mohd Waheed Roomi and Tatiana Kalinovsky and Aleksandra Niedzwiecki and Matthias Rath},
  journal={Journal of Cardiovascular Pharmacology},
  year={2007},
  volume={50},
  pages={541-547}
}
Extracellular matrix (ECM) function and structure are severely compromised at atherosclerotic lesion sites, contributing to initiation and progression of the disease. This study investigated whether ECM biological properties would be beneficially affected by exposure to nutrients essential for collagen synthesis and posttranslational modification. Confluent layers of human aortic smooth muscle cells (SMC) grown on collagen substrate were cultured in the presence of the tested compounds for 7 to… 
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