Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex.

@article{Long2018ExtracellularMC,
  title={Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex.},
  author={Katherine R. Long and Ben Newland and Marta Florio and Nereo Kalebic and Barbara Langen and Anna Kolterer and Pauline Wimberger and Wieland B Huttner},
  journal={Neuron},
  year={2018},
  volume={99 4},
  pages={
          702-719.e6
        }
}
Neocortical expansion, thought to underlie the cognitive traits unique to humans, is accompanied by cortical folding. This folding starts around gestational week (GW) 20, but what causes it remains largely unknown. Extracellular matrix (ECM) has been previously implicated in neocortical expansion and here we investigate the potential role of ECM in the formation of neocortical folds. We focus on three specific ECM components localized in the human fetal cortical plate (CP): hyaluronan and… CONTINUE READING
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