Extracellular Matrix 1 (ECM1) Expression Is a Novel Prognostic Marker for Poor Long-Term Survival in Breast Cancer: A Hospital-Based Cohort Study in Iowa

@article{Lal2009ExtracellularM1,
  title={Extracellular Matrix 1 (ECM1) Expression Is a Novel Prognostic Marker for Poor Long-Term Survival in Breast Cancer: A Hospital-Based Cohort Study in Iowa},
  author={MSc Geeta Lal and Samad Hashimi and Brian J Smith and PhD Charles F. Lynch and PhD Lurong Zhang and PhD Robert A. Robinson and PhD FACS Ronald J. Weigel},
  journal={Annals of Surgical Oncology},
  year={2009},
  volume={16},
  pages={2280-2287}
}
Previous work in a small, unselected series showed that up to 83% of breast carcinomas overexpress ECM1 by immunohistochemistry (IHC) and that tumors with lymph node metastases are more likely to be ECM1-positive. We sought to further evaluate ECM1 expression and its effect on prognosis in an unselected cohort of patients with breast cancer. ECM1 expression was examined by IHC in 134 women diagnosed with invasive breast cancer between 1986 and 1989 and correlated with clinical parameters and… CONTINUE READING