Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E.

@article{Li2017ExtracellularIB,
  title={Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E.},
  author={Zhihua Li and Yadong Li and Yanwei Bi and Hui Zhang and Yufeng Yao and Qihan Li and Wei Cun and Shaozhong Dong},
  journal={Journal of virology},
  year={2017},
  volume={91 15}
}
Interactions between hepatitis C virus (HCV) and lipoproteins in humans play an important role in the efficient establishment of chronic infection. Apolipoprotein E (ApoE) on the HCV envelope mediates virus attachment to host cells as well as immune evasion. This interaction is thought to occur in hepatocytes, as ApoE plays dual functions in HCV assembly and maturation as well as cell attachment. In the present study, we found that secreted ApoE (sApoE) can also bind to viral particles via its… CONTINUE READING