Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3.

  title={Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3.},
  author={Dominique Thuringer and Gaetan Jego and Guillaume Wettstein and Olivier Terrier and Laurent Cronier and Nadhir Yousfi and Sophie H{\'e}brard and Andre Bouchot and Adonis Hazoum{\'e} and Anne-Laure Joly and Martin G Gleave and Manuel Rosa-Calatrava and {\'E}ric Solary and Carmen Garrido},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={27 10},
The heat-shock protein 27 (HSP27) is up-regulated in tumor cells and released in their microenvironment. Here, we show that extracellular HSP27 has a proangiogenic effect evidenced on chick chorioallantoic membrane. To explore this effect, we test the recombinant human protein (rhHSP27) at physiopathological doses (0.1-10 μg/ml) onto human microvascular endothelial cells (HMECs) grown as monolayers or spheroids. When added onto HMECs, rhHSP27 dose-dependently accelerates cell migration (with a… CONTINUE READING
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