Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages

@article{Salari2012ExtracellularHA,
  title={Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages},
  author={Samira Salari and Tara Seibert and Yong-Xiang Chen and Tieqiang Hu and Chunhua Shi and Xiaoling Zhao and Charles M. Cuerrier and Joshua E. Raizman and Edward R. O’Brien},
  journal={Cell Stress and Chaperones},
  year={2012},
  volume={18},
  pages={53-63}
}
Heat shock protein 27 (HSP27) shows attenuated expression in human coronary arteries as the extent of atherosclerosis progresses. In mice, overexpression of HSP27 reduces atherogenesis, yet the precise mechanism(s) are incompletely understood. Inflammation plays a central role in atherogenesis, and of particular interest is the balance of pro- and anti… CONTINUE READING