Extracellular Glutamate and Other Metabolites in and Around RG2 Rat Glioma: An Intracerebral Microdialysis Study

@article{Behrens2000ExtracellularGA,
  title={Extracellular Glutamate and Other Metabolites in and Around RG2 Rat Glioma: An Intracerebral Microdialysis Study},
  author={Peter F Behrens and Helen Langemann and R J Strohschein and J. Draeger and Jurgen Henning},
  journal={Journal of Neuro-Oncology},
  year={2000},
  volume={47},
  pages={11-22}
}
The current study determined the extracellular content of glutamate, 10 additional amino acids, lactate, glucose and some antioxidants in a rodent model of malignant glioma, its peritumoral space and the adjacent cortex. RG2 tumors were induced in the right frontal cortex of Fischer-344 rats (n=10) by a standardized procedure to obtain a maximum sagittal… CONTINUE READING