Extracellular Fibrils of Pathogenic Yeast Cryptococcus gattii Are Important for Ecological Niche, Murine Virulence and Human Neutrophil Interactions

@inproceedings{Springer2010ExtracellularFO,
  title={Extracellular Fibrils of Pathogenic Yeast Cryptococcus gattii Are Important for Ecological Niche, Murine Virulence and Human Neutrophil Interactions},
  author={Deborah J Springer and Ping Ren and R. Raina and Yimin Dong and Melissa J. Behr and Bruce F. McEwen and Samuel S. Bowser and William A. Samsonoff and Sudha Chaturvedi and Vishnu Chaturvedi},
  booktitle={PloS one},
  year={2010}
}
Cryptococcus gattii, an emerging fungal pathogen of humans and animals, is found on a variety of trees in tropical and temperate regions. The ecological niche and virulence of this yeast remain poorly defined. We used Arabidopsis thaliana plants and plant-derived substrates to model C. gattii in its natural habitat. Yeast cells readily colonized scratch-wounded plant leaves and formed distinctive extracellular fibrils (40-100 nm diameter x500-3000 nm length). Extracellular fibrils were observed… CONTINUE READING
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