Extracellular Events Induced by γ‐Hydroxybutyrate in Striatum: A Microdialysis Study

@article{Hechler1991ExtracellularEI,
  title={Extracellular Events Induced by $\gamma$‐Hydroxybutyrate in Striatum: A Microdialysis Study},
  author={Viviane Hechler and Serge Gobaille and Jean-Jacques Bourguignon and Michel Maitre},
  journal={Journal of Neurochemistry},
  year={1991},
  volume={56}
}
Abstract: The modification of dopamine release and accumulation induced by γ‐hydroxybutyrate (GHB) was studied using both striatal slices and in vivo microdialysis of caudate‐putamen. GHB inhibited dopamine release for ∼5–10 min in vitro, and this was associated with an accumulation of dopamine in the tissue. Subsequently, there was an increase in dopamine release. In the microdialysis experiments, low doses of GHB inhibited dopamine release, whereas higher doses strongly increased release; the… 

Pharmacologically induced cessation of burst activity in nigral dopamine neurons: Significance for the terminal dopamine efflux

The results of this combined electrophysiological and microdialysis study support the idea that firing pattern may be an important physiological modulatory mechanism for the release of terminal neurotransmitter.
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