• DOI:10.1111/j.1471-4159.1991.tb02012.x
Corpus ID: 86392963

Extracellular Events Induced by γ‐Hydroxybutyrate in Striatum: A Microdialysis Study

@article{Hechler1991ExtracellularEI,
  title={Extracellular Events Induced by γ‐Hydroxybutyrate in Striatum: A Microdialysis Study},
  author={V. Hechler and S. Gobaille and J. Bourguignon and M. Maitre},
  journal={Journal of Neurochemistry},
  year={1991},
  volume={56}
}

V. Hechler, S. Gobaille, +1 author M. Maitre

Published 1991

Biology

Journal of Neurochemistry

Abstract: The modification of dopamine release and accumulation induced by γ‐hydroxybutyrate (GHB) was studied using both striatal slices and in vivo microdialysis of caudate‐putamen. GHB inhibited dopamine release for ∼5–10 min in vitro, and this was associated with an accumulation of dopamine in the tissue. Subsequently, there was an increase in dopamine release. In the microdialysis experiments, low doses of GHB inhibited dopamine release, whereas higher doses strongly increased release; the… CONTINUE READING

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