Extracellular Domains of CD8α and CD8ß Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4+ T Cells

@inproceedings{Loenen2013ExtracellularDO,
  title={Extracellular Domains of CD8α and CD8\ss Subunits Are Sufficient for HLA Class I Restricted Helper Functions of TCR-Engineered CD4+ T Cells},
  author={Marleen M. van Loenen and Renate S. Hagedoorn and Renate de Boer and J H Frederik Falkenburg and Mirjam H M Heemskerk},
  booktitle={PloS one},
  year={2013}
}
By gene transfer of HLA-class I restricted T-cell receptors (TCRs) (HLA-I-TCR) into CD8(+) as well as CD4(+) T-cells, both effector T-cells as well as helper T-cells can be generated. Since most HLA-I-TCRs function best in the presence of the CD8 co-receptor, the CD8αß molecule has to be co-transferred into the CD4(+) T-cells to engineer optimal helper T-cells. In this study, we set out to determine the minimal part of CD8αβ needed for optimal co-receptor function in HLA-I-TCR transduced CD4… CONTINUE READING