Extracellular DNA traps promote thrombosis.

  title={Extracellular DNA traps promote thrombosis.},
  author={Tobias A Fuchs and Alexander Brill and Daniel D{\"u}rschmied and Daphne Schatzberg and Marc Monestier and Daniel Durant Myers and Shirley K. Wrobleski and Thomas W. Wakefield and John H. Hartwig and Denisa D Wagner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 36},
Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and antimicrobial proteins. Microbes are immobilized in NETs and encounter a locally high and lethal concentration of effector proteins. Recent studies show that NETs are formed inside the vasculature in infections and noninfectious diseases. Here we report that NETs provide a heretofore unrecognized scaffold and stimulus for thrombus formation. NETs… CONTINUE READING
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