Extracellular DNA traps promote thrombosis.

@article{Fuchs2010ExtracellularDT,
  title={Extracellular DNA traps promote thrombosis.},
  author={Tobias A Fuchs and Alexander Brill and Daniel D{\"u}rschmied and Daphne Schatzberg and Marc Monestier and Daniel Durant Myers and Shirley K. Wrobleski and Thomas W. Wakefield and John H. Hartwig and Denisa D Wagner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 36},
  pages={15880-5}
}
Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and antimicrobial proteins. Microbes are immobilized in NETs and encounter a locally high and lethal concentration of effector proteins. Recent studies show that NETs are formed inside the vasculature in infections and noninfectious diseases. Here we report that NETs provide a heretofore unrecognized scaffold and stimulus for thrombus formation. NETs… CONTINUE READING
Highly Influential
This paper has highly influenced 32 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
438 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 438 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…