Extracellular DNA traps promote thrombosis

@article{Fuchs2010ExtracellularDT,
  title={Extracellular DNA traps promote thrombosis},
  author={T. Fuchs and A. Brill and D. D{\"u}rschmied and Daphne Schatzberg and M. Monestier and D. Myers and S. Wrobleski and T. Wakefield and J. Hartwig and D. Wagner},
  journal={Proceedings of the National Academy of Sciences},
  year={2010},
  volume={107},
  pages={15880 - 15885}
}
  • T. Fuchs, A. Brill, +7 authors D. Wagner
  • Published 2010
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and antimicrobial proteins. Microbes are immobilized in NETs and encounter a locally high and lethal concentration of effector proteins. Recent studies show that NETs are formed inside the vasculature in infections and noninfectious diseases. Here we report that NETs provide a heretofore unrecognized scaffold and stimulus for thrombus formation. NETs… CONTINUE READING

    Paper Mentions

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