Extracellular Adenosine Generation in the Regulation of Pro-Inflammatory Responses and Pathogen Colonization

@inproceedings{Alam2015ExtracellularAG,
  title={Extracellular Adenosine Generation in the Regulation of Pro-Inflammatory Responses and Pathogen Colonization},
  author={Mohammad Samiul Alam and Matthew G. Costales and Christopher Cavanaugh and Kristina Williams and Ivana Vancurova},
  booktitle={Biomolecules},
  year={2015}
}
Adenosine, an immunomodulatory biomolecule, is produced by the ecto-enzymes CD39 (nucleoside triphosphate dephosphorylase) and CD73 (ecto-5'-nucleotidase) by dephosphorylation of extracellular ATP. CD73 is expressed by many cell types during injury, infection and during steady-state conditions. Besides host cells, many bacteria also have CD39-CD73-like machinery, which helps the pathogen subvert the host inflammatory response. The major function for adenosine is anti-inflammatory, and most… CONTINUE READING

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