Extracellular Acidosis Stimulates NHE2 Expression through Activation of Transcription Factor Egr-1 in the Intestinal Epithelial Cells

@inproceedings{Muthusamy2013ExtracellularAS,
  title={Extracellular Acidosis Stimulates NHE2 Expression through Activation of Transcription Factor Egr-1 in the Intestinal Epithelial Cells},
  author={Saminathan Muthusamy and Ming ‐ Jun Cheng and Jong-Jin Jeong and Anoop 4 Kumar and Pradeep K. Dudeja and Jaleh Malakooti},
  booktitle={PloS one},
  year={2013}
}
Na(+)/H(+) exchangers (NHEs) play important roles in regulating internal pH (pHi), cell volume and neutral Na(+) absorption in the human intestine. Earlier studies have shown that low extracellular pH (pHe) and metabolic acidosis increases the expression and function of NHE1-3 genes. However, transcriptional mechanisms involved remained unknown. Therefore, we investigated the molecular mechanisms underlying acid-induced NHE2 expression in C2BBe1 and SK-CO15 intestinal epithelial cells… CONTINUE READING

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