Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration.

@article{Kawamura2012ExtracellularAM,
  title={Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration.},
  author={Hiroki Kawamura and Toshihiko Kawamura and Yasuhiro Kanda and Takahiro Kobayashi and Toru Abo},
  journal={Immunology},
  year={2012},
  volume={136 4},
  pages={448-58}
}
Macrophages are the major source of the chemokines macrophage inflammatory protein-2 (MIP-2) and keratinocyte-derived chemokine (KC), which play a major role in neutrophil migration to sites of inflammation. Although extracellular ATP from inflammatory tissues induces several immune responses in macrophages, it is unclear whether ATP-stimulated macrophages affect neutrophil migration. Therefore, the aim of the present study was to investigate the role of ATP-induced MIP-2 production by… CONTINUE READING

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