Extracellular ATP protects pancreatic duct epithelial cells from alcohol-induced damage through P2Y1 receptor-cAMP signal pathway

@article{Seo2016ExtracellularAP,
  title={Extracellular ATP protects pancreatic duct epithelial cells from alcohol-induced damage through P2Y1 receptor-cAMP signal pathway},
  author={Jong Bae Seo and Seung-Ryoung Jung and Bertil Hille and Duk-Su Koh},
  journal={Cell Biology and Toxicology},
  year={2016},
  volume={32},
  pages={229-247}
}
Extracellular adenosine-5′-triphosphate (ATP) regulates cell death and survival of neighboring cells. The detailed effects are diverse depending on cell types and extracellular ATP concentration. We addressed the effect of ATP on ethanol-induced cytotoxicity in epithelial cells, the cell type that experiences the highest concentrations of alcohol. Using pancreatic duct epithelial cells (PDEC), we found that a micromolar range of ATP reverses all intracellular toxicity mechanisms triggered by… CONTINUE READING
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