Extracellular ATP prevents the release of stored Ca2+ by autonomic agonists in rat submandibular gland acini.

@article{Hurley1993ExtracellularAP,
  title={Extracellular ATP prevents the release of stored Ca2+ by autonomic agonists in rat submandibular gland acini.},
  author={Tara Hurley and D. DeWayne Shoemaker and Michael P. Ryan},
  journal={The American journal of physiology},
  year={1993},
  volume={265 6 Pt 1},
  pages={C1472-8}
}
In dose-dependent fashion, extracellular ATP reduces the increase in cytosolic Ca2+ concentration ([Ca2+]o) due to mobilization of cellular Ca2+ stores by both epinephrine [half-maximal inhibitory concentration (IC50) = 35.7 +/- 12.9 microM; Hill coefficient (NH) = -2.0 +/- 0.7, n = 8] and by carbachol (IC50 = 27.0 +/- 7.0 microM, NH = -2.3 +/- 0.7, n = 9). Inhibition is due to ATP4- but does not result from any emptying or inaccessibility of Ca2+ stores, which are readily mobilized by… CONTINUE READING

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