Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor.

@article{Gerasimovskaya2002ExtracellularAI,
  title={Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor.},
  author={Evgenia V. Gerasimovskaya and Shama Ahmad and Carl W. White and Peter L Jones and Todd C. Carpenter and Kurt R Stenmark},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 47},
  pages={44638-50}
}
Important autocrine/paracrine functions for the adenine nucleotides have been proposed in several tissues. We addressed the possibility that extracellular ATP would modulate/mediate hypoxia-induced adventitial fibroblast growth. Acute hypoxia (3% O(2), 10-60 min) increased extracellular ATP concentrations in adventitial fibroblasts and in lung microvascular endothelial cells, and chronic hypoxia (3% O(2), 14-30 days) markedly attenuated the rate of extracellular ATP hydrolysis by ecto… CONTINUE READING
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