Extracellular ATP inhibits IL-1-induced MMP-1 expression through the action of CD39/nucleotidase triphosphate dephosphorylase-1 on human gingival fibroblasts.

@article{Nemoto2013ExtracellularAI,
  title={Extracellular ATP inhibits IL-1-induced MMP-1 expression through the action of CD39/nucleotidase triphosphate dephosphorylase-1 on human gingival fibroblasts.},
  author={Eiji Nemoto and Kazuhiro Gotoh and Masahiro Tsuchiya and Yukihiko Sakisaka and Hidetoshi Shimauchi},
  journal={International immunopharmacology},
  year={2013},
  volume={17 3},
  pages={513-8}
}
Extracellular adenosine triphosphate (ATP) is sequentially dephosphorylated by two ectoenzymes: CD39/nucleotidase triphosphate dephosphorylase (ENTPD) and CD73/5'-ectonucleotidase (5'-NT). Adenosine, its notable metabolite, may elicit potent anti-inflammatory responses. We examined whether the CD39-adenosinergic axis may exist in gingival fibroblasts and… CONTINUE READING