Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells.

@article{Hrtel2007ExtracellularAI,
  title={Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells.},
  author={Frauke Viola H{\"a}rtel and Christoph Walter Rodewald and Muhammad Javaid Aslam and Dursun Guenduez and Lisa Hafer and Joachim Neumann and Hans Michael Piper and Thomas Noll},
  journal={Cardiovascular research},
  year={2007},
  volume={74 3},
  pages={487-96}
}
OBJECTIVES Extracellular ATP stabilizes the endothelial barrier and inactivates the contractile machinery of endothelial cells. This inactivation relies on dephosphorylation of the regulatory myosin light chain (MLC) due to an activation of the MLC phosphatase (MLCP). To date, activation and function of MLCP in endothelial cells are only partially understood. METHODS Here, the mechanism of extracellular ATP-mediated activation of MLCP was analyzed in human endothelial cells from umbilical… CONTINUE READING
11 Citations
42 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Preparation of endothelial cells from microand macrovascular origin

  • SC Peters, A Reis, T. Noll
  • 2005

Similar Papers

Loading similar papers…