Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells.

@article{Hrtel2007ExtracellularAI,
  title={Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells.},
  author={F. H{\"a}rtel and C. Rodewald and M. Aslam and D. G{\"u}nd{\"u}z and L. Hafer and J. Neumann and H. Piper and T. Noll},
  journal={Cardiovascular research},
  year={2007},
  volume={74 3},
  pages={
          487-96
        }
}
OBJECTIVES Extracellular ATP stabilizes the endothelial barrier and inactivates the contractile machinery of endothelial cells. This inactivation relies on dephosphorylation of the regulatory myosin light chain (MLC) due to an activation of the MLC phosphatase (MLCP). To date, activation and function of MLCP in endothelial cells are only partially understood. METHODS Here, the mechanism of extracellular ATP-mediated activation of MLCP was analyzed in human endothelial cells from umbilical… Expand
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