Extracellular ATP-induced currents in astrocytes: involvement of a cation channel.

  title={Extracellular ATP-induced currents in astrocytes: involvement of a cation channel.},
  author={Wolfgang Walz and Gerald Gimpl and Carsten Ohlemeyer and Helmut Kettenmann},
  journal={Journal of neuroscience research},
  volume={38 1},
Whole-cell currents were measured with the perforated patch clamp technique in cultured rat astrocytes to analyze the underlying ionic mechanism for a P2-purinoceptor-mediated depolarization. ATP (100 microM) induced an inward current with a mean amplitude of 130 pA and an EC50 of 17 microM. The response desensitized during a 1 min application. Replacement of extracellular Na+ with NMDG or K+ abolished the ATP-evoked inward current. Replacement of Na+ with choline, however, resulted in an ATP… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 27 extracted citations

ATP released from astrocytes mediates glial calcium waves.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…