Extracellular ATP-induced currents in astrocytes: involvement of a cation channel.

@article{Walz1994ExtracellularAC,
  title={Extracellular ATP-induced currents in astrocytes: involvement of a cation channel.},
  author={Wolfgang Walz and Gerald Gimpl and Carsten Ohlemeyer and Helmut Kettenmann},
  journal={Journal of neuroscience research},
  year={1994},
  volume={38 1},
  pages={12-8}
}
Whole-cell currents were measured with the perforated patch clamp technique in cultured rat astrocytes to analyze the underlying ionic mechanism for a P2-purinoceptor-mediated depolarization. ATP (100 microM) induced an inward current with a mean amplitude of 130 pA and an EC50 of 17 microM. The response desensitized during a 1 min application. Replacement of extracellular Na+ with NMDG or K+ abolished the ATP-evoked inward current. Replacement of Na+ with choline, however, resulted in an ATP… CONTINUE READING

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