Extracellular ATP in the lymphohematopoietic system: P2Z purinoceptors off membrane permeabilization.

@article{Persechini1998ExtracellularAI,
  title={Extracellular ATP in the lymphohematopoietic system: P2Z purinoceptors off membrane permeabilization.},
  author={Pedro Muanis Persechini and Rodrigo da Cunha Bisaggio and J L Alves-Neto and Robson Coutinho-Silva},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={1998},
  volume={31 1},
  pages={25-34}
}
The effects of extracellular nucleosides and nucleotides on many organs and systems have been recognized for almost 50 years. The effects of extracellular ATP (ATPo), UTPo, ADPo, and other agonists are mediated by P2 purinoceptors. One of the most dramatic effects of ATPo is the permeabilization of plasma membranes to low molecular mass solutes of up to 900 Da. This effect is evident in several cells of the lymphohematopoietic system and is supposed to be mediated by P2Z, an ATP(4-)-activated… CONTINUE READING
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