Extracellular ADP regulates lesion-induced in vivo cell proliferation and death in the zebrafish retina.

@article{Battista2009ExtracellularAR,
  title={Extracellular ADP regulates lesion-induced in vivo cell proliferation and death in the zebrafish retina.},
  author={Ariadna Gabriela Battista and Mar{\'i}a Soledad Ricatti and Diego E. Pafundo and Marien A Gautier and Maria Paula Faillace},
  journal={Journal of neurochemistry},
  year={2009},
  volume={111 2},
  pages={
          600-13
        }
}
Regeneration and growth that occur in the adult teleost retina by neurogenesis have been helpful in identifying molecular and cellular mechanisms underlying cell proliferation and differentiation. In this report, we demonstrate that endogenous purinergic signals regulate cell proliferation induced by a cytotoxic injury of the adult zebrafish retina which mainly damages inner retinal layers. Particularly, we found that ADP but not ATP or adenosine significantly enhanced cell division as assessed… CONTINUE READING
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