Extracellular 8-oxo-dG as a sensitive parameter for oxidative stress in vivo and in vitro.

@article{Haghdoost2005Extracellular8A,
  title={Extracellular 8-oxo-dG as a sensitive parameter for oxidative stress in vivo and in vitro.},
  author={Siamak Haghdoost and Stefan Czene and Ingemar N{\"a}slund and Sven Skog and Mats Harms-Ringdahl},
  journal={Free radical research},
  year={2005},
  volume={39 2},
  pages={153-62}
}
8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) is one of the mutagenic base modifications produced in DNA by the reaction of reactive oxygen species. The biological significance of 8-oxo-dG is shown by the existence of repair pathways that are able to recognize and remove this lesion from both DNA and the nucleotide pool. The final outcome of these evolutionarily conserved repair mechanisms in man is excretion of 8-oxo-dG/8-oxo-Gua from the intracellular to extracellular milieu including the… CONTINUE READING

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