Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.

@article{Kristiansen2010Extracellular2O,
  title={Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.},
  author={Helle Kristiansen and Christina A Scherer and Maralee McVean and Shawn Iadonato and Susanne Vends and Karthiga Thavachelvam and Thomas Bielefeldt Steffensen and Kristy A. Horan and T. Kuri and Friedemann Weber and S\oren R Paludan and Rune Hartmann},
  journal={Journal of virology},
  year={2010},
  volume={84 22},
  pages={11898-904}
}
The 2'-5' oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a correlation between the concentration of freely circulating OAS protein in sera from hepatitis C patients and their clinical prognosis. Here we demonstrate that extracellular OAS1 enters into cells and possesses a strong antiviral activity, both in vitro and in vivo, which is independent of RNase L. The OAS protein directly inhibits viral… CONTINUE READING