Extra-embryonic function of Rb is essential for embryonic development and viability

  title={Extra-embryonic function of Rb is essential for embryonic development and viability},
  author={Lizhao Wu and Alain de Bruin and Harold I. Saavedra and Maja Starovic and Anthony J. Trimboli and Ying Yang and Jana Opavska and Pamela Wilson and John F Thompson and Michael C. Ostrowski and Thomas J Rosol and Laura A. Woollett and Michael A. Weinstein and James C Cross and M. L. Robinson and Gustavo Leone},
The retinoblastoma (Rb) gene was the first tumour suppressor identified. Inactivation of Rb in mice results in unscheduled cell proliferation, apoptosis and widespread developmental defects, leading to embryonic death by day 14.5 (refs 2–4). However, the actual cause of the embryonic lethality has not been fully investigated. Here we show that loss of Rb leads to excessive proliferation of trophoblast cells and a severe disruption of the normal labyrinth architecture in the placenta. This is… CONTINUE READING
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