Extra domain B fibronectin as a target for near-infrared fluorescence imaging of rheumatoid arthritis affected joints in vivo.

@article{Vollmer2009ExtraDB,
  title={Extra domain B fibronectin as a target for near-infrared fluorescence imaging of rheumatoid arthritis affected joints in vivo.},
  author={Sonja Vollmer and Axel Vater and Kai Licha and Ines Gemeinhardt and Ole Gemeinhardt and Jan Voigt and Bernd Ebert and J{\"o}rg Schnorr and Matthias Taupitz and Rainer Macdonald and Michael Schirner},
  journal={Molecular imaging},
  year={2009},
  volume={8 6},
  pages={
          330-40
        }
}
Abstract We investigated a molecular imaging approach for the detection of collagen-induced arthritis in rats by targeting the extra domain B (ED-B) of the extracellular matrix protein fibronectin. ED-B is a highly conserved domain (identical in human and rats) that is produced by alternative splicing during embryonic development and during vascular remodeling such as angiogenesis. The hallmark of rheumatoid arthritis is synovitis leading to both angiogenesis in the synovium and the promotion… CONTINUE READING

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