Extra-colonic manifestations of familial adenomatous polyposis coli.

  title={Extra-colonic manifestations of familial adenomatous polyposis coli.},
  author={Alison H Trainer},
  journal={Advances in experimental medicine and biology},
The most important clinical manifestation of Familial Adenomatous Polyposis (FAP) is a profuse polyposis predisposing to colorectal cancer. This clinical picture emphasises the fundamental cellular role of APC in colorectal tumorigenesis. As prophylactic colorectal surgery has significantly reduced the mortality associated with this disorder, other less penetrant signs and symptoms of the condition are becoming more clinically relevant. Highlighting these problems will help improve the quality… CONTINUE READING

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