Extra-articular rheumatoid arthritis

@article{Turesson2013ExtraarticularRA,
  title={Extra-articular rheumatoid arthritis},
  author={C. Turesson},
  journal={Current Opinion in Rheumatology},
  year={2013},
  volume={25},
  pages={360–366}
}
  • C. Turesson
  • Published 2013
  • Medicine
  • Current Opinion in Rheumatology
Purpose of reviewTo discuss recent findings on the epidemiology and pathogenesis of extra-articular manifestations in rheumatoid arthritis (RA), and provide an update on the literature on treatment of patients with extra-articular RA (ExRA) manifestations. Recent findingsExRA is associated with increased comorbidity and mortality. Several surveys suggest that some ExRA manifestations, in particular vasculitis, occur less frequently than previously reported. This is probably due to improved… Expand
Beyond the joints, the extra-articular manifestations in rheumatoid arthritis.
TLDR
The extra-articular features of RA remain, despite the improvement of joint damage, a major diagnostic and therapeutic challenge, since these are associated with a poor prognosis and need to be early recognized and promptly managed. Expand
EXTRA-ARTICULAR MANIFESTATIONS OF RHEUMATOID ARTHRITIS, NOW
TLDR
The clinical aspects of major ExRA are reviewed, focusing on incidence, clinical features, and therapeutic approaches, and how modern immunosuppressive therapy can change the outcome. Expand
Extra-articular Manifestation of Rheumatoid Arthritis
Introduction: Rheumatoid arthritis is an autoimmune disorder of unknown etiology characterized by symmetric, erosive synovitis, and in some cases, extra-articular involvement. Most patientsExpand
Interstitial Lung Disease as the Initial Manifestation of Rheumatoid Arthritis: A Case Report and Review of the Literature
TLDR
Extra-articular involvement of RA can be observed as initial presentation of the disease in a handful of cases, however, RA diagnosis must be achieved to correctly manage these patients which can at that time receive targeted therapeutic interventions. Expand
Lung Disease Associated with Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an immune-mediated disease that primarily affects joints. In the 2000s, numerous novel antirheumatic agents, called biological disease-modifying antirheumatic drugsExpand
Severe Extra-articular Manifestations of Rheumatoid Arthritis in Absence of Concomitant Articular Activity Following Longstanding Spontaneous Remission. A Case Report
TLDR
The case of a 56-year-old woman diagnosed with active RA, whose arthritis subsides spontaneously during pregnancy despite the lack of treatment with disease-modifying anti-rheumatic drugs, and the development of severe extra-articular manifestations of RA in absence of concomitant articular activity is reported. Expand
The Multifaceted Aspects of Interstitial Lung Disease in Rheumatoid Arthritis
TLDR
A greater understanding of the disease process is necessary in order to improve the therapeutic approach to ILD and RA itself and to reduce the burden of this severe extra-articular manifestation. Expand
Rheumatoid arthritis–associated interstitial lung disease: an overview of epidemiology, pathogenesis and management
TLDR
The available literature support that methotrexate, leflunomide, abatacept and rituximab play beneficial roles in the prevention and treatment of RA-ILD and disease-modifying anti-rheumatic drugs in RA lack strong evidence in the onset or worsening of ILD. Expand
Management of Interstitial Lung Disease Associated with Rheumatoid Arthritis
Interstitial Lung Disease (ILD) is a common extra-articular manifestation of Rheumatoid Arthritis (RA) and that causes mortality in RA patients. Usual Interstitial Pneumonia (UIP) and Non SpecificExpand
Severe extra-articular manifestations of rheumatoid arthritis in absence of concomitant joint involvement following long-term spontaneous remission. A case report.
TLDR
The case of a 56 year-old woman diagnosed with active RA at the age of 40, who subsides spontaneously during pregnancy despite the lack of treatment with disease-modifying anti-rheumatic drugs, and the development of severe extra-articular manifestations of RA in absence of concomitant articular activity is reported. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 79 REFERENCES
Management of extra-articular disease manifestations in rheumatoid arthritis
TLDR
Advances in the understanding of the pathogenesis of rheumatoid arthritis and developments of new, more specific drugs may be of particular benefit to patients with extra-articular disease. Expand
Epidemiology of extra‐articular manifestations in rheumatoid arthritis
TLDR
The methodological issues involved in the study of ExRA manifestations are discussed, suggested criteria that have been used in clinical studies are presented, and important surveys of the epidemiology of extra‐articular RA are reviewed. Expand
Extra-articular manifestations of rheumatoid arthritis: An update.
TLDR
Understanding the complexity of EAM and their management remains a challenge for clinicians, especially since the effectiveness of drug therapy on EAM has not been systematically evaluated in randomized clinical trials. Expand
Extra-articular manifestations in a community-based sample of patients with rheumatoid arthritis: incidence and relationship to treatment with TNF inhibitors
TLDR
The data show a lower incidence of ExRA in patients treated with TNF inhibitors but further studies with a larger sample size are needed for a more accurate estimate of the size of the effect. Expand
Predictors of extra-articular manifestations in rheumatoid arthritis.
TLDR
Although present in the majority of cases as well as controls, the disease associated HLA-DRB1 subtypes were not significant predictors of ExRA and Extraarticular disease was predicted by antinuclear antibodies and rheumatoid nodules. Expand
Extra-articular rheumatoid arthritis: prevalence and mortality.
TLDR
Serositis and cutaneous vasculitis were predominant extra-articular manifestations of rheumatoid arthritis; and mortality was greater in the ExRA than in the non-ExRA subgroup, perhaps due to a high frequency of associated heart disease. Expand
The extra-articular features of rheumatoid arthritis. A systematic analysis of 127 cases.
TLDR
The results obtained in hospitalized patients indicate that the manifestations of rheumatoid arthritis form a spectrum in which extra-articular features should be considered as classic criteria of rhematoid arthritis, and these extra-Articular features appear to have an important bearing on prognosis. Expand
Factors associated with the development of vasculitis in rheumatoid arthritis: results of a case-control study.
TLDR
The development of RV is associated with male gender, extra-articular features, and a severe course of RA as indicated by the presence of joint destruction and need for intensive treatment with antirheumatic drugs. Expand
Severe extra-articular disease manifestations are associated with an increased risk of first ever cardiovascular events in patients with rheumatoid arthritis.
TLDR
It is suggested that systemic extra-articular disease is a major determinant of cardiovascular morbidity in rheumatoid arthritis. Expand
Vasculitis in rheumatoid arthritis
TLDR
This model implies that rheumatoid arthritis patients can be separated into two groups: individuals with synovial disease and individuals withsynovial plus extra-articular disease, and is supported by immunogenetic analysis describing an accumulation of vasculitis patients with rheumatic arthritis among HLA-DRB1*0401 homozygotes. Expand
...
1
2
3
4
5
...