Extra-adrenal effects of metyrapone include inhibition of the 11-oxoreductase activity of 11 beta-hydroxysteroid dehydrogenase: a model for 11-HSD I deficiency.

@article{Raven1995ExtraadrenalEO,
  title={Extra-adrenal effects of metyrapone include inhibition of the 11-oxoreductase activity of 11 beta-hydroxysteroid dehydrogenase: a model for 11-HSD I deficiency.},
  author={Peter W Raven and Stuart A. Checkley and Norman F. Taylor},
  journal={Clinical endocrinology},
  year={1995},
  volume={43 5},
  pages={637-44}
}
BACKGROUND AND OBJECTIVE Previous studies suggesting effects of metyrapone on extra-adrenal corticosteroid metabolism have involved significant alterations in plasma cortisol. We have therefore studied effects of metyrapone on urinary excretion of steroids in a group of patients treated concurrently with hydrocortisone so that changes in plasma cortisol… CONTINUE READING