Extinguishing the sparks.


The mechanical contraction of cardiac muscle is triggered by membrane depolarization through a process known as calcium-induced calcium-release (CICR). The structural basis of CICR is exquisite in its detail. At thousands of distinct locations throughout the myocyte, the junctional sarcoplasmic reticulum (JSR) membrane approaches to within ~12 nm of the t… (More)
DOI: 10.1016/j.bpj.2013.04.010