Extinction of liver-specific functions in hybrids between differentiated and dedifferentiated rat hepatoma cells.


A cross has been performed between dedifferentiated rat hepatoma cells and the differentiated cells from which they were derived. 10 hybrid clones, containing the complete chromosome sets of both parents, show extinction of 4 liver-specific enzymes: tyrosine aminotransferase (E.C., alanine aminotransferase (E.C., and the liver-specific… (More)