Extinction of cocaine self-administration produces alterations in corticotropin releasing factor gene expression in the paraventricular nucleus of the hypothalamus.

@article{Crespo2003ExtinctionOC,
  title={Extinction of cocaine self-administration produces alterations in corticotropin releasing factor gene expression in the paraventricular nucleus of the hypothalamus.},
  author={Jos{\'e} Antonio Crespo and Jorge Manzanares and Jos{\'e} Mar{\'i}a Oliva and Javier Corchero and Carmen Garc{\'i}a-Lecumberri and Emilio Ambrosio},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={117 2},
  pages={160-7}
}
The long-term effect of cocaine self-administration on corticotropin releasing factor (CRF) mRNA content in the hypothalamic CRF-containing neurons has not yet been established. The purpose of this study was to examine the time course effects of the extinction of cocaine self-administration behavior on CRF gene expression in the paraventricular nucleus of the hypothalamus (PVN) using in situ hybridization histochemistry (IHHS). Seventy-two littermate male Lewis rats were randomly assigned in… CONTINUE READING