Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements


Inactivation of the E-cadherin cell adhesion molecule is believed critical in the development and behavior of many epithelial cancers, though mutations in the E-cadherin gene account for inactivation in only a fraction of cases. In many breast cancer lines, E-cadherin transcription is extinguished, but the role and significance of alterations in trans… (More)
DOI: 10.1038/sj.onc.1203336


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