Extinction Learning in Humans Role of the Amygdala and vmPFC

@article{Phelps2004ExtinctionLI,
  title={Extinction Learning in Humans Role of the Amygdala and vmPFC},
  author={Elizabeth A. Phelps and Mauricio R. Delgado and Katherine I. Nearing and Joseph E LeDoux},
  journal={Neuron},
  year={2004},
  volume={43},
  pages={897-905}
}
Understanding how fears are acquired is an important step in translating basic research to the treatment of fear-related disorders. However, understanding how learned fears are diminished may be even more valuable. We explored the neural mechanisms of fear extinction in humans. Studies of extinction in nonhuman animals have focused on two interconnected brain regions: the amygdala and the ventral medial prefrontal cortex (vmPFC). Consistent with animal models suggesting that the amygdala is… Expand
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It is suggested that the vmPFC receives convergent information from other brain regions, such as contextual information from the hippocampus, to determine the circumstances under which extinction or fear will be recalled. Expand
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The results suggest that the lateral PFC regions engaged by cognitive emotion regulation strategies may influence the amygdala, diminishing fear through similar vmPFC connections that are thought to inhibit the amygdala during extinction. Expand
FROM THE NEUROBIOLOGY OF EXTINCTION TO IMPROVED CLINICAL TREATMENTS
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The modulation of pathways underlying fear learning and extinction, such as the ones presented in this review, in combination with extinction‐based exposure therapy, represents promising avenues for therapeutic intervention in the treatment of human fear related disorders. Expand
Medial Prefrontal Cortex
  • M. Maroun
  • Psychology, Medicine
  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2013
Anxiety disorders are among the most common mental health problems; deficits in extinction have been implicated as a possible risk factor for the development of these disorders. Fear extinctionExpand
Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants
TLDR
The results partially support the notion of a shared neuroanatomy between human and rodent models of extinction processes, and encourage an expanded account of the neural basis of human fear extinction. Expand
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