Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition.

Abstract

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric 'gates' to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

DOI: 10.1039/c6nh00202a

Cite this paper

@article{Won2017ExternallyCG, title={Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition.}, author={Sangho Won and Sarah-Jane Richards and Marc Walker and Matthew I Gibson}, journal={Nanoscale horizons : the home for rapid reports of exceptional significance in nanoscience and nanotechnolgy}, year={2017}, volume={2 2}, pages={106-109} }