External validity of risk models: Use of benchmark values to disentangle a case-mix effect from incorrect coefficients.

@article{Vergouwe2010ExternalVO,
  title={External validity of risk models: Use of benchmark values to disentangle a case-mix effect from incorrect coefficients.},
  author={Yvonne Vergouwe and Karel G. M. Moons and Ewout Willem Steyerberg},
  journal={American journal of epidemiology},
  year={2010},
  volume={172 8},
  pages={971-80}
}
Various performance measures related to calibration and discrimination are available for the assessment of risk models. When the validity of a risk model is assessed in a new population, estimates of the model's performance can be influenced in several ways. The regression coefficients can be incorrect, which indeed results in an invalid model. However, the distribution of patient characteristics (case mix) may also influence the performance of the model. Here the authors consider a number of… CONTINUE READING

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