External pancreatic secretion after bombesin infusion in man.

@article{Basso1975ExternalPS,
  title={External pancreatic secretion after bombesin infusion in man.},
  author={Nicola Basso and Sergio Giri and Giovanna Improta and Emanuele Lezoche and Pietro Melchiorri and Massimo Percoco and Vincenzo Speranza},
  journal={Gut},
  year={1975},
  volume={16},
  pages={994 - 998}
}
The effect of bombesin on external pancreatic secretion was studied in seven healthy volunteers and intwo patients with a two-thirds gastrectomy and a pancreatic fistula. After bombesin infusion (15 ng/kg/min), gastrin levels were significantly raised in all volunteers, but remained at basal levels in the gastrectomized patients. Bombesin was effective in stimulating pancreatic secretion in all patients. The volume of secretion increased tow-fold when compared with basal volume. Amylase and… Expand
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TLDR
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Effect of immunoneutralisation of cholecystokinin on bombesin-stimulated pancreatic enzyme secretion in the rat
TLDR
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TLDR
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TLDR
It is concluded that rat pancreatic duct cells possess receptors for bombesin and substance P, in addition to 'secretin‐preferring’ receptors, which places the site of inhibition mediated by substance P at a point in the secretory mechanism distal to the generation of cyclic AMP. Expand
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References

SHOWING 1-10 OF 16 REFERENCES
EVIDENCE OF CHOLECYSTOKININ RELEASE BY BOMBESIN IN THE DOG
TLDR
It is suggested that bombesin acts on the gall bladder and the exocrine pancreas through release of cholecystokinin from the duodenal mucosa throughRelease of secretin could be demonstrated and it is likely that the releasing activity of bombsin is limited, in the field of gastrointestinal peptides, to those belonging to the gastrin‐cholecystokerin family. Expand
GASTRIN RELEASE BY BOMBESIN IN THE DOG
TLDR
It is concluded that bombesin is a potent releaser of gastrin from the antral mucosa and the inhibitory effect of acidification could be surmounted by prolonging the duration ofBombesin infusion. Expand
Gastrin release in postoperative ulcer patients: evidence for release of duodenal gastrin.
TLDR
It is indicated that food entering the duodenum is capable of stimulating gastrin release after the gastric antrum has been resected, and vagotomy in man increases basal and postprandial serum gastrin concentrations. Expand
Simultaneous measurements of total pancreatic, biliary, and gastric outputs in man using a perfusion technique.
TLDR
The technique was used to show that total pancreatic enzyme output after intraduodenal stimulation by perfused amino acids was identical with that obtained after a maximally tolerated dose of pancreozymin given by vein, suggesting that conventional stimuli cannot attain maximal secretory capacity for enzymes. Expand
Production and evaluation of antibodies for the radioimmunoassay of gastrin.
TLDR
Only three antisera had antibodies with sufficient binding energy for radioimmunochemical determination of low physiologic concentrations of serum-gastrin (K0≥1011l/mol), and one of them reacted with cholecystokinin to an extent that made it unsuited for gastrin determinations in biologic fluids. Expand
The preparation and properties of two new chromogenic substrates of trypsin.
TLDR
Preliminary studies indicate that benzoyl dl -arginine p -nitroanilide hydrochloride is also hydrolyzed by papain, and that of l -LPA is in a more alkaline region than normally found for trypsin substrates. Expand
New chromogenic substrate for determination of serum amylase activity.
TLDR
A rapid assay for serum amylase activity has been developed based on the use of a new chromogenic substrate—Cibachron Blue—amylose, and excellent correlation was observed with a saccharometric amyl enzyme procedure. Expand
Laboratory evaluation of a chromogenic amylase method.
  • F. Dalal, S. Winsten
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • 1971
TLDR
Minor modifications of the commercial method seem to result in a sensitive and reliable procedure, which compares favorably with the amyloclastic assay, and the substrate appears to react within a broad pH range. Expand
Observations on a new simplified dye method for assessing amylase activity.
A method utilizing a newly synthesized dye-labeled amylose substrate (Cibachron Blue F3GA-Amylose) provides a simple and reliable means for assaying serum amylase activity. The results correlatedExpand
Effects of bombesin on pancreatic secretion and gallbladder motility in dogs
  • 1975
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