External genitalia abnormalities in male rats exposed in utero to finasteride, a 5 alpha-reductase inhibitor.

@article{Clark1990ExternalGA,
  title={External genitalia abnormalities in male rats exposed in utero to finasteride, a 5 alpha-reductase inhibitor.},
  author={R. L. Clark and Joseph M. Antonello and Scott J. Grossman and L. David Wise and Carol R Anderson and W J Bagdon and Srinivasa Prahalada and James S Macdonald and Richard T. Robertson},
  journal={Teratology},
  year={1990},
  volume={42 1},
  pages={91-100}
}
A series of studies was conducted to determine the developmental toxicity of the 5 alpha-reductase inhibitor finasteride (MK-0906) in rats. This compound was administered orally once daily to pregnant rats during various extended treatment periods during gestation. F1 offspring were evaluated on Day 20 of gestation as well as postnatally through mating to produce an F2 generation. MK-0906 treatment induced dosage-related incidences of hypospadias (penischisis) in male offspring with a threshold… CONTINUE READING