External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells.

@article{Kase1998ExternalAI,
  title={External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells.},
  author={Akihiko Kase and Maria H. Johansson and Mats Y. Olsson-Alheim and Klas K{\"a}rre and Pia H{\"o}glund},
  journal={Journal of immunology},
  year={1998},
  volume={161 11},
  pages={6133-8}
}
Expression of the H-2Dd-specific inhibitory receptor Ly49A on murine NK cells is subject to MHC class I-dependent modulation in vivo. As a result, NK cells in H-2Dd-transgenic mice express low cell surface levels of Ly49A, whereas NK cells from nontransgenic C57BL/6 (B6) mice express high levels. The purpose of this study was to assess the role of MHC class I molecules on the NK cell itself vs those on surrounding cells in this calibration and to test whether the Ly49A levels are subject to… CONTINUE READING
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In search of the “missing self”: MHC molecules and NK cell recognition

  • Ljunggren, H.-G, K. Kärre
  • Immunol. Today
  • 1990
Highly Influential
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