Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore.

@article{Gupta2003ExtentOT,
  title={Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore.},
  author={Jyoti Sen Gupta and Paul Lindsell},
  journal={Molecular membrane biology},
  year={2003},
  volume={20 1},
  pages={
          45-52
        }
}
Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel have previously been shown to alter the selectivity of the channel between different anions, suggesting that part of the pore may form an anion 'selectivity filter'. However, the full extent of this selectivity filter region and the location of anion binding sites in the pore are currently unclear. As a result, comparisons between CFTR and other classes of Cl(-) channel of… CONTINUE READING
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