Extent of resection and radiotherapy in GBM: A 1973 to 2007 surveillance, epidemiology and end results analysis of 21,783 patients.

@article{Zinn2013ExtentOR,
  title={Extent of resection and radiotherapy in GBM: A 1973 to 2007 surveillance, epidemiology and end results analysis of 21,783 patients.},
  author={Pascal O. Zinn and Rivka R. Colen and Ekkehard M. Kasper and J.-K. Burkhardt},
  journal={International journal of oncology},
  year={2013},
  volume={42 3},
  pages={
          929-34
        }
}
Surgery, radiation and chemotherapy are the standard of care for GBM patients, however, the impact of extent of resection (EOR) and radiotherapy (RT) on patient survival across age groups has not been established. Therefore, we present the current largest study on EOR and RT in GBM over the past three decades. Using the population based Surveillance, Epidemiology and End Results (SEER) registry, we identified a total of 21,783 GBM patients (1973-2007). Survival analysis based on EOR and RT was… 
View on PubMed
spandidos-publications.com
61 Citations
Highly Influential Citations
1
Background Citations
11
Methods Citations
2
Results Citations
1

61 Citations

Citation Type

Citation Type

Prognostic Implications of Extent of Resection in Glioblastoma: Analysis from a Large Database.
Patient and treatment factors associated with survival among pediatric glioblastoma patients: A Surveillance, Epidemiology, and End Results study
The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma
TLDR
GTR of glioblastoma performed with ioUS guidance was associated with prolonged OS and PFS, and IoUS should be compared to other resection control devices in larger patient cohorts.
Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.
TLDR
This analysis represents the largest systematic review and only quantitative systematic review to date performed on this subject and shows that GTR substantially improves overall and progression-free survival, but the quality of the supporting evidence is moderate to low.
Sex, Age, Anatomic Location, and Extent of Resection Influence Outcomes in Children With High-grade Glioma.
TLDR
GTR significantly improved overall survival for both glioblastoma multiforme and anaplastic astrocytoma patients, and female patients showed a much larger survival benefit from GTR than male patients.
Treatment results and outcome in elderly patients with glioblastoma multiforme – A retrospective single institution analysis
Disparities in receipt of modern concurrent chemoradiotherapy in glioblastoma
TLDR
Widespread adoption of adjuvant chemoradiotherapy after resection or biopsy for GBM appears to improve OS, and specific disparities in the use of chemotherapy that may be targeted to improve patient access to care are identified.
Prior malignancy impact on survival outcomes of glioblastoma multiforme; population-based study
TLDR
The findings suggest that the broad practice of excluding patients with a prior history of cancer should be reconsidered as it may adversely affect accrual, trial completion rates, and generalizability of the results.
Glioblastoma in England: 2007-2011.
Risk of subsequent cancer among pediatric, adult and elderly patients following a primary diagnosis of glioblastoma multiforme: a population-based study of the SEER database
TLDR
The risk of a second malignancy in GBM patients is 1.8%, and associated with certain patient and treatment factors.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
The timing of cranial radiation in elderly patients with newly diagnosed glioblastoma multiforme
TLDR
Although effort should be made to initiate radiotherapy as soon as possible after surgical resection/biopsy, a brief delay similar to that experienced by the cohort does not have a significant impact on survival.
An extent of resection threshold for newly diagnosed glioblastomas.
TLDR
For patients with newly diagnosed GBMs, aggressive EOR equates to improvement in overall survival, even at the highest levels of resection, and stepwise improvement in survival was evident even in the 95%-100% EOR range.
Improved survival time trends for glioblastoma using the SEER 17 population-based registries
TLDR
Encouraging results are suggested and suggest that the current treatment of glioblastoma nationwide is now associated with an improved survival compared to previous time cohorts.
Effectiveness of radiotherapy for elderly patients with glioblastoma.
A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival.
TLDR
Gross-total tumor resection is associated with longer survival in patients with GBM, especially when other predictive variables are favorable.
Prognostic factors influencing clinical outcomes of glioblastoma multiforme.
TLDR
Age at diagnosis, preoperative Karnofsky Performance Scale (KPS) score, KPS score change at 2 weeks postoperation, involvement of brain lobe, involved of eloquent cortex or deep structure, Ki-67 expression level and adjuvant chemotherapy correlate significantly with the prognosis of patients with GBM.
Independent association of extent of resection with survival in patients with malignant brain astrocytoma.
TLDR
In the authors' experience with both primary and secondary resection of malignant brain astrocytomas, increasing extent of resection was associated with improved survival independent of age, degree of disability, WHO grade, or subsequent treatment modalities used.
Clinical Significance of Molecular Biomarkers in Glioblastoma
TLDR
MGMT promoter methylation is a strong, independent prognostic factor for OS in GBM and the presence of EGFR amplification, maintenance of PTEN and wild-type p53 and p16 were each associated with trends towards improved survival.
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.
Radiotherapy for glioblastoma in the elderly.
TLDR
Radiotherapy results in a modest improvement in survival, without reducing the quality of life or cognition, in elderly patients with glioblastoma.
...
1
2
3
...