Extent of regression dilution for established and novel coronary risk factors: results from the British Regional Heart Study.

@article{Emberson2004ExtentOR,
  title={Extent of regression dilution for established and novel coronary risk factors: results from the British Regional Heart Study.},
  author={Jonathan Robert Emberson and Peter Whincup and Richard W. Morris and Mary Walker and Gordon D. O. Lowe and Ann Rumley},
  journal={European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology},
  year={2004},
  volume={11 2},
  pages={
          125-34
        }
}
BACKGROUND Imprecision in measurement of risk factors leads to underestimation of associations with disease outcomes (through regression dilution bias). We examine the extent of this bias for established and novel risk factors for coronary heart disease (CHD) and consider the consequences for CHD prevention. DESIGN Prospective cardiovascular study of middle-aged British men followed up over 20 years. METHODS Repeated measurements of blood lipids, blood pressure and insulin were available at… CONTINUE READING
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