Extent of linkage disequilibrium in Holstein cattle in North America.

@article{Sargolzaei2008ExtentOL,
  title={Extent of linkage disequilibrium in Holstein cattle in North America.},
  author={Mehdi Sargolzaei and Flavio S. Schenkel and Gerald B. Jansen and Lawrence R Schaeffer},
  journal={Journal of dairy science},
  year={2008},
  volume={91 5},
  pages={
          2106-17
        }
}
The success of fine-scale mapping and genomic selection depends mainly on the strength of linkage disequilibrium (LD) between markers and causal mutations. With Lewontin's measure of LD (known as D'), high levels of LD that extend over several million base pairs have been reported in livestock. However, this measure of LD can be strongly biased upward by small samples and by low allele frequencies. The aim of this study was to characterize the level and extent of LD in Holstein cattle in North… CONTINUE READING

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